Friday, 1st August
21st International Conference on Biological Inorganic Chemistry 2025
Days
Monday, 28th July
Tuesday, 29th July
Wednesday, 30th July
Thursday, 31st July
Friday, 1st August
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Speakers
Registration Opens
8:00AM - 3:30PM
Friday, 1st August
Terrace Theatre Foyer
Plenary Session 9 - Clotilde Policar
8:30AM - 9:15AM
Friday, 1st August
Seaside Ballroom AB
Chair: Hannah Shafaat
Metal complexes in cells: from the design of metal-based catalytic antioxidants as enzymes mimics to application in cells and in vivo
-
Clotilde Policar
Biological Cu 1.0
9:30AM - 11:00AM
Friday, 1st August
Seaside Ballroom AB
Chair: Teera Chantarojsiri
Signal strapping—a proteomic search technique for the discovery of metalloproteins
-
Paul H Walton
Replication and mimicry of metalloenzyme active sites in peptide frameworks
-
Andy I Nguyen
Bioinspired functional models of copper-containing Lytic Polysaccharide Monooxygenase
-
A. Jalila Simaan
Recent advances in C-H hydroxylation using Cu, H
2
O
2
and directing groups
-
Isaac Garcia-Bosch
Clusters 1.0
9:30AM - 11:00AM
Friday, 1st August
Seaside Room 1
Chair: Patrick Holland
Bioinspired Cubic Metal-Sulfur Clusters for N
2
Activation
-
Yasuhiro Ohki
The function of Mak16 in ribosome biogenesis depends on its [4Fe-4S] cluster
-
Antonio J. Pierik
Cracking the CIA code: apo-client identification by the cytosolic iron sulfur cluster assembly (CIA) system
-
Deborah Perlstein
Understanding the Catalytic Mechanism of Sulfur Mobilization for Iron-Sulfur Cluster Formation within the SUF Pathway of
Staphylococcus aureus
-
Richard C Holz
Metallodrug/Probes 1.0
9:30AM - 11:00AM
Friday, 1st August
Seaside Room 7
Chair: Allon Hochbaum
Inhibiting mitochondrial calcium uptake with ruthenium and osmium coordination complexes
-
Justin J Wilson
From coordination chemistry to photomedicine: 4d and 5d metalloporphyrin analogues
-
Abhik Ghosh
Exploring the potential of synthetic heme protein models as injectable antidotes against highly toxic gases
-
Hiroaki Kitagishi
Hybridized metal-organic capsules binding with enzymes for biomimetic catalysis
-
Chunying Duan
ArMs 1.0
9:30AM - 11:00AM
Friday, 1st August
Seaside Room 4
Chair: Anne Duhme-Klair
Design and Directed Evolution of Artificial Metalloenzymes for Selective Catalysis
-
Jared Lewis
Repurposing Cupin Protein as Artificial Metalloenzymes that Catalyze Stereoselective Reactions
-
Nobutaka Fujieda
Oxygenase mimicking immobilized metal complex catalysts
-
Shiro Hikichi
Metalloenzyme engineering with genetic code expansion
-
Alexandria (Ali) Deliz Liang
Copper and Health 1.0
9:30AM - 11:00AM
Friday, 1st August
Seaside Room 5
Chair: Woon Ju Song
Sulfide as a Regulator of Copper Trafficking
-
Ruma Banerjee
Targeting copper homeostasis to enhance antifungal activity
-
Katherine J. Franz
Cancer-cell-selective cytotoxicity of dicopper complexes supported by various amide-tether dinucleating ligands
-
Masahito Kodera
Copper metabolism in
Trypanosoma cruzi
: An Achilles’ heel for Chagas disease?
-
Julia Cricco
Biomolecular Modification 1.0
9:30AM - 11:00AM
Friday, 1st August
Seaside Room 3
Chair: Alison Fout
pH dependence of dye-decolorizing and demetallate activities of a dye-decolorizing peroxidase from
Vibrio cholerae
-
Takeshi Uchida
Building Precision, Functional Glyconanoassemblies through Supramolecular Design
-
Julia Stauber
Chemical modification of biomolecules using hydrophilic olefin metathesis catalysts
-
Takashi Matsuo
Morning Coffee Break
11:00AM - 11:20AM
Friday, 1st August
Seaside Pre-function & Lobby area
Non-Heme Iron 1.0
11:20AM - 12:50PM
Friday, 1st August
Seaside Ballroom AB
Chair: Carsten Krebs
Understanding the rich repertoire of the oxoiron(IV) intermediate in enzymatic C–H activation
-
J. Martin Bollinger, Jr.
Kinetic Stabilization of High-Spin Terminal Iron Oxo Complexes through Confinement
-
Brandon Barnett
Spectroscopic characterization of nitric oxide reactions with nonheme diiron proteins
-
Pierre Moenne-Loccoz
Characterization of bacterial oxygen-independent hydroxylases
-
Lauren J Rajakovich
Metals in Medicine 1.0
11:20AM - 12:50PM
Friday, 1st August
Seaside Room 1
Chair: Hugh Harris
Metal-Binding Isosteres for Fragment-Based Drug Discovery
-
Seth M Cohen
Impact of copper on amyloid pathology within Alzheimer’s disease
-
Jiyeon Han
Catalytic Amyloids Promote Carbon Dioxide Hydration with Efficiencies that Rival those of Native Carbonic Anhydrases.
-
Ivan Korendovych
Carboplatin-Based Pt(IV)-Deferoxamine Conjugates as Multifunctional Agents for Cancer and Infection Theranostics
-
Hristo Varbanov
Molecular Systems 1.0
11:20AM - 12:50PM
Friday, 1st August
Seaside Room 7
Chair: Jaeheung Cho
PCET is the Engine of Radical Enzymology: The RNR Paradigm
-
Daniel Nocera
Photo-reduction of NO
3
–
to NH
3
Using CH
4
as a Reductant in Re Catalysis
-
Takahiro Matsumoto
Syntheses, X-ray crystal structures, and spectroscopic studies of bio-inspired iron nitrosyl complexes
-
Lijuan Li
The development of Pt-PROTACs to degrade Pt(II) binding proteins
-
Darren M Griffith
Metallocluster 1.0
11:20AM - 12:50PM
Friday, 1st August
Seaside Room 4
Chair: Jonathan Rittle
Roles for structural and functional asymmetry in nitrogenase-like DPOR and electron transfer
-
Edwin Antony
Heterologous synthesis of a simplified nitrogenase analog in
Escherichia coli
-
Yilin Hu
Electronic Structure and Two-Electron Oxidation Reactivity Modulated by Coordination Spheres in a Mn/Fe R2-like Ligand-Binding Oxidase
-
Yuri Lee
Architecture, Catalysis and Regulation of the Nitrogenase-Like Methylthio-Alkane Reductase for cleavage of Volatile Organic Sulfur Compounds
-
Justin North
Regulations and Probes 1.0
11:20AM - 12:50PM
Friday, 1st August
Seaside Room 5
Chair: Mario Rivera
Structural insights into the regulation of Methanogen Nitrogenase
-
Rajnandani Kashyap
Development of a diagnostic tool for the determination of Wilson disease
-
C Derrick Quarles Jr
Histidine phosphorylation – a novel mechanism of metalloprotein regulation?
-
Amy M. Barrios
Probing metalloprotein dynamics with gated electron transfer reactions
-
Bruce E Bowler
Mitochondrial Higd1A Enhances Proton-to-Electron Stoichiometry in Cytochrome
c
Oxidase
-
Minoru Kubo
Bioinspired Complexes 3.0
11:20AM - 12:50PM
Friday, 1st August
Seaside Room 3
Chair: Rex Handford
Catalytic Studies of Iron-Superoxo Complexes
-
Way-Zen Lee
Multivariate analysis applied to the metal-mediated catalytic oxidation of organic substrates.
-
Fernando R Xavier
Bioinspired Reactivity of β-Diketiminate and β-Thioketiminate Copper Coordination Complexes
-
Sodio Hsu
Exploring the unique metal dependent regioselectivity of a 3His-1Glu bound dioxygenase, acireductone dioxygenase (ARD), via a family of biomimetic model complexes.
-
Santiago Toledo
Lunch Break
12:50PM - 1:50PM
Friday, 1st August
Dinuclear Cofactors 1.0
1:50PM - 3:20PM
Friday, 1st August
Seaside Ballroom AB
Chair: J. Martin Bollinger, Jr.
Elucidating and exploiting structure-function relationships in a Mn/Fe oxidase
-
Hannah S. Shafaat
Discovery of Manganese-Dependent Monooxygenases
-
Jonathan Rittle
Electron paramagnetic resonance and X-ray crystallography revealed the unique cold adaptation mechanism in di-Mn enzyme
-
Masaki Horitani
Beyond C-H Bond Activation: Versatile Bond Breaking and Bond Forming Reactivities by Co
2
(μ-O)
2
Diamond Core Complexes
-
Dong Wang
Synthetic Systems 3.0
1:50PM - 3:20PM
Friday, 1st August
Seaside Room 1
Chair: Nathaniel Szymczak
Metal-Oxygen Intermediates in Dioxygen Activation and Formation Reactions
-
Wonwoo Nam
Functional Synthetic Mimics of Carbonic Anhydrase
-
Jenny Yang
Aromatic Fulvalenes: Synthesis, Characterization, and Metalation
-
Eunsung Lee
Using biologically inspired metal and organic redox couples to electrocatalytically convert O
2
to water at low effective overpotentials
-
Christian R Goldsmith
Zn/Co-Biochemistry 1.0
1:50PM - 3:20PM
Friday, 1st August
Seaside Room 7
Protein quality control in the bacterial periplasm triggered by zinc starvation
-
Alejandro J Vila
Rational Design of a Synthetic Trinuclear Zinc Center in a Protein Scaffold: Combining Non-native Catalysis with Native Protein Activity
-
Yasunori Okamoto
H
2
S signals via Zinc Finger protein persulfidation
-
Sarah Michel
All about Fe 1.0
1:50PM - 3:20PM
Friday, 1st August
Seaside Room 4
Chair: Rachel Codd
Deconstructing heme in the “hidden world” of the microbiome
-
Jennifer DuBois
The role of Fe and Fe supplementation in human health: are we helping or hurting ?
-
Peggy L. Carver
Biosynthetic gene clusters encoding siderophore biosynthesis
-
Alison Butler
Structural Studies: An Operon Implicated in Te Detox and Mn Homeostasis
-
Kelly N Chacon
Ni-Biochemistry 1.0
1:50PM - 3:20PM
Friday, 1st August
Seaside Room 5
Chair: Richard Holz
Discovery and characterization of novel Ni, Fe-CODHs using a bioinformatic approach
-
Henrik Land
Metal selectivity and translocation mechanism in transmembrane Nickel and Cobalt Transporters (NiCoTs) from pathogenic bacteria
-
Gabriele Meloni
How anaerobic microbes make and break methane: Structure of the active Ni(I) state and mechanism of methyl-Coenzyme M reductase
-
Stephen W Ragsdale
Assembly and Activation of Methyl-coenzyme M Reductase
-
Steven O Mansoorabadi
Artificial metalloenzymes as tools for targeted electrocatalytic Carbon-Carbon coupling
-
Kevin Enrique Rivera Cruz
Methods to Probe Function 2.0
1:50PM - 3:20PM
Friday, 1st August
Seaside Room 3
Chair: Joshua Telser
Illuminating Heme Trafficking and Signaling in Health and Disease
-
Amit R. Reddi
Watching enzymes at work: using X-ray spectroscopy and crystallography to decipher reaction mechanisms of biological catalysts
-
Jan Kern
Molecular mechanism of allocrite transport in ABC transporter revealed by time-resolved spectroscopy
-
Tetsunari Kimura
Thermostable group III alcohol dehydrogenase separated into two domains: Characterization of each domain and activity evaluation in a domain-mixed system
-
Nobuhumi Nakamura
Afternoon Coffee Break
3:20PM - 3:40PM
Friday, 1st August
Seaside Pre-function & Lobby area
Plenary Session 10 - Tom Ward
3:40PM - 4:25PM
Friday, 1st August
Seaside Ballroom AB
Chair: Andrew Borovik
Artificial metalloenzymes for
in vivo
catalysis: challenges and opportunities
-
Thomas R Ward
Next destination & Closing Remarks
4:25PM - 4:30PM
Friday, 1st August
Seaside Ballroom AB
Chairs: Andrew Borovik & Celia Goulding
← Thursday