Patrick J Farmer
I am a bioinorganic chemist by training, specializing in the reactivity of nitric oxide and related species with metalloenzymes. My graduate work under Marcetta Darensbourg at TAMU centered on synthesis and reactivity of model complexes for NiFe hydrogenases. My first postdoctoral fellowship with Christian Amatore at Ecole Normale Supérieure was on redox reactivity, as measured electrochemically; in a second postdoc under Harry Gray at Caltech, I gained expertise handling metallo-proteins and enzymes, and in the use of photo-induce electron transfers and transient spectroscopy. I continued this interest at UC Irvine as an assistant professor, using direct electrochemical measurements of the catalytic reduction of nitrite by myoglobin and other heme proteins, which led to the first characterized HNO-heme protein adduct. I collaborated with the a large cancer group which found melanoma cells in culture had an unusual sensitivity to lipophilic Cu-chelators, which was one of the first examples of cuprotosis. At Baylor, we have used modern mass spectroscopic methods to characterize the small oxoacids of sulfur such as HSOH and HOSOH within cells.
Abstracts this author is presenting: