Russ Hille
Biographical Sketch
Russ Hille
Distinguished Professor of Biochemsitry
University of California, Riverside
Professional Preparation:
• Texas Tech University B.S. 06/74 Chemistry
• Rice University Ph.D. 06/79 Biochemistry
• University of Michigan post-doctoral 08/81 Biochemistry
Appointments:
2014 – present Distinguished Professor of Biochemistry, University of California, Riverside
2007 – 2014 Professor, Department of Biochemistry, University of California, Riverside
1995 – 2007 Professor, Dept Mol Cell Biochemistry, The Ohio State University
1995 – 2007 Professor, Department of Chemistry, The Ohio State University
1990 – 1995 Assoc Professor, Dept Mol Cell Biochemistry, The Ohio State University
1985 – 1990 Asst Professor, Dept Mol Cell Biochemistry, The Ohio State University
1982 – 1985 Asst Professor, Department of Biological Chemistry, University of Michigan
1981 – 1982 Lecturer, Department of Biological Chemistry, University of Michigan
Representative Peer-Reviewed Publications of past 10 years: (of 172 total)
Niks, D, Duvvuru, J., Escalona, M. & Hille, R. (2016) Spectroscopic and kinetic characterization of the soluble, NAD+-dependent formate dehydrogenase from Ralstonia eutropha, J. Biol. Chem. 291, 1162-1174.
Yu, X., Niks, D., Mulchandani, A., & Hille, R. (2017) Efficient reduction of CO2 by the molybdenum-containing formate dehydrogenase from Cupriavidus necator. J. Biol. Chem. 292, 16872-16879.
Pacheco, J. Niks, D., Haffner, N., & Hille, R. (2018) Tungsten-substituted DMSO reductase from Rhodopacter sphaeroides exhibits a W(V) species with an unusually intense UV/visible absorption spectrum. J. Biol. Inorg. Chem. 23, 295-301.
Niks, D., and Hille R. (2018) Molybdenum- and tungsten-containing formate dehydrogenases and formylmethanofuran dehydrogenases: structure, mechanism and cofactor insertion. Protein Sci., DOI 10.1002/pro.3498.
Kalimuthu, P., Petitgenet, M., Niks, D., Dingwall, S., Hille, R., and Bernhardt, P.V. (2020) The oxidation-reduction and electrocatalytic properties of CO dehydrogenase from Oligotropha carboxidovorans. Biochim. Biophys. Acta 1861, #148118.
Young, T., Niks, D., Hakopian, S., Tam, T.K., Yu, X., Hille, R. and Blaha, G. (2020) Crystallographic and kinetic analyses of the FdsBG subcomplex of the cytosolic formate dehydrogenase FdsABG from Cupriavidus necator. J. Biol. Chem., 295, 6570-6585.
Vigil, W., Jr., Tran, J., Niks, D., Schut, G.J., Ge, Xiaoxuan, Adams, M.W.W., and Hille, R. (2022) The reductive half-reaction of two bifurcating electron-transferring flavoproteins. Evidence for changes in flavin reduction potentials in the course of the reaction. J. Biol. Chem 298, DOI 10.1016/j.jbc.2022.101927.
Vigil, W., Jr., Nguyen, D., Niks, D., & Hille R. (2023) Rapid-reaction kinetics of the butyryl-CoA dehydrogenase from Megasphaera elsdenii. J. Biol. Chem. 299, #104853. doi.org/10.1016/j.jbc.2023.104853
Kalimuthu, P, Hakopian, S., Niks, D. Hille, R. & Bernhardt, P.V. (2023) The reversible electrochemical conversion of formate and CO2 by formate dehydrogenase from Cupriavidus necator. J. Phys. Chem. B., 127, 8382-8392. doi/10.1021/acs.jpcb.3c04652
Ortiz, S, Niks, D., Wiley, S. Lubner, C.E. & Hille, R. (2023) Rapid-reaction kinetics of the bifurcating NAD+-dependent NADPH:ferredoxin oxidoreductase NfnI from Pyrococcus furiosus. J. Biol. Chem. 299. doi.org/10.1016/j.jbc.2023.105403
Harmer, J., Hakopian, S., Niks, D., Hille, R., & Bernhardt, P. (2023) Redox characterization of complex molybdenum enzyme formate dehydrogenase from Cupriavidus necator”. J. Am. Chem. Soc. 145, 25850-255863. DOI: 10.1021/jacs.3c10199
Nguyen, D., Vigil, W., Jr., Niks, D., & Hille R. The Rapid-reaction Kinetics of an Electron-Bifurcating Flavoprotein, the crotonyl-CoA-dependent NADH:ferredoxin oxidoreductase EtfAB:bcd. J. Biol. Chem., DOI.org.10.1016/j.jbc.2024.107745..
Niks, D., Hakopian, S., Canchola, A., Lin, Y.0H., & Hille, R. (2024) On the mechanism of action of formate dehydrogenases. J. Am. Chem. Soc., DOI.org/10.1021/jacs.4c07376.
Giang, P.D, Niks, D., Hakopian, S. Hille, R., & Bernhardt, P.V. (2025) Reversible NAD+/NADH electrochemistry catalyzed by the FdsBG subcomplex of formate dehydrogenase. Chem. Sci., 16, 6035-6049.