Electron bifurcation, the splitting of electron pairs into high and low energy pools, underpins energy storage and catalysis in living systems. Redox networks that bifurcate electrons do so at low thermodynamic cost, accomplishing a Maxwell’s Demon like process. The inner workings of electron bifurcating enzymes are poorly understood, especially with respect to how energy dissipating (short-circuiting) reactions are avoided between the high- and low-energy electron transport pathways. A key feature of electron bifurcation networks is that they link three redox pools at very different potentials. I will show how we are modeling electron bifurcation networks and will describe classes of redox energy landscapes that naturally insulate the bifurcation networks from short-circuiting. The correlated many-particle flow in these networks is, in fact, essential for their function. I will review the physical principles that appear to underpin electron bifurcation networks, will contrast them with single-electron transfer networks, and will explore open questions and opportunities.