Synthesis ,characterization, biocidal and cytotoxic activities of Mn (II) and Hg(II) bridging complexes.
Vinay Kumar Srivastava and Khushboo Rani
Bioinorganic Research Laboratory, Department of Chemistry, D.S. College ,Aligarh, Raja Mahendra Pratap Singh State Govt. University, Aligarh, 202001 U.P INDIA
Abstract
Dithiocarbamate transition metal complexes, which are organic molecules, are promising and appealing pharmacological targets for controlling and managing antibiotic resistant microbial populations. Transition metal complexes Mn[C10H16O2N2S4]2 and Hg[C10H16O2N2S4]2 FTIR, UV-Visible, NMR techniques employed for the structural determination of complexes. Afterwards, the synthesized compounds were subjected to analysis in order to evaluate their biocidal and anticancer activities. Spectral Studies results suggest that the dithiocarbamate ion has capacity to form robust bridging compounds with Mn (II) and Hg (II) cations.These complexes have a reduced inclination for the creation of dative π bonds from the metal ion or to the sulfur atom. The results of the activity against bacteria show that the generated metal complexes are far more active than the ligand fragment. The theory of chelation implies there is a decrease in the ability of metallic compounds to undergo polarization or increase in hydrogen bonding can lead to an increased susceptibility of the complex to dissolve in lipids, hence boosting its antimicrobial effectiveness. The compounds were tested for their therapeutic efficacy against a particular malignant cell. The findings of the HeLa cell line investigation suggest that Mn (II) and Hg (II) Compounds show promise for chemotherapeutic alternatives in the quest for anticancer medications. We have documented the methods of preparation, analysis, biocidal properties, and studies on apoptosis of Mn (II) and Hg (II) compounds with dithiocarbamate ligand. The complexes under investigation have demonstrated antibacterial, antifungal, and anticancer properties.
Acknowledgement: Financial support by the Department of Science & Technology, UP CST, Lucknow, India for research grant (Grant Number CST/CHEM/D-646,Project ID-4058).
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