Establishing a foundation for the development of synthetic antibiotics targeting the iron-sulfur cluster biogenesis pathway of Staphylococcus aureus (#489)
Connor Nelson
1
,
Emily Sabo
1
,
Nupur Tyagi
2
,
Veronica Stark
1
,
Katelyn Aasman
1
,
Ava Garrison
1
,
Ashlynne Bogema
3
,
Christine N Morrison
1
,
Jeffrey M Boyd
2
,
Richard C Holz
1
- Chemistry, Colorado School of Mines, Golden, COLORADO, United States
- Department of Biochemistry and Microbiology, Rutgers University, New Brunswick, New Jersey, United States
- Quantitative Biosciences and Engineering, Colorado School of Mines, Golden, Colorado, United States
Publish consent withheld
- (1) Hudspeth, J.D.; Boncella, A.E.; Sabo, E.T.; Andrews T.; Boyd, J.M.; Morrison, C.M. Structural and Biochemical Characterization of Staphylococcus aureus Cysteine Desulfurase Complex SufSU. ACS Omega, 2022, 7 (48), 44124–44133. DOI: https://doi.org/10.1021/acsomega.2c05576.
- (2) Roberts, C.A.; Al-Tameemi, H.M.; Mashruwala, A.A.; Rosario-Cruz, Z.; Chauhan, U.; Sause, W.E.; Torres, V.J.; Belden, W.J.; Boyd, J.M. The Suf Iron-Sulfur Cluster Biosynthetic System Is Essential in Staphylococcus aureus, and Decreased Suf Function Results in Global Metabolic Defects and Reduced Survival in Human Neutrophils. Infect. Immun., 2017, 85 (6), DOI: https://doi.org/10.1128/iai.00100-17.
- (3) Fujishiro, T.; Terahata, T.; Kunichika, K.; Yokoyama, N.; Maruyama, C.; Asai, K.; Takahashi, Y. Zinc-Ligand Swapping Mediated Complex Formation and Sulfur Transfer between SufS and SufU for Iron–Sulfur Cluster Biogenesis in Bacillus subtilis. J. Am. Chem. Soc. 2017, 139 (51), 18464–18467, DOI: https://doi.org/10.1021/jacs.7b11307.
- (4) Sabo, E.; Nelson, C.; Tyagi, N.; Stark, V.; Aasman, K.; Morrison, C.N.; Boyd, J.M.; Holz, R.C. Development of a Spectrophotometric Assay for the Cysteine Desulfurase from Staphylococcus aureus. Antibiotics 2025, 14 (2), 129; https://doi.org/10.3390/antibiotics14020129.